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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Husain M, Bain SC, Holst AG, Mark T, Rasmussen S, Lingvay I

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Timeline and Severity of Post-Meal Diarrhea During GLP-1 Therapy Clinical data from semaglutide trials shows that diarrhea typically begins within the first week or two of starting therapy or increasing doses, peaks around weeks 3 to 6, and improves significantly by weeks 8 to 12 as your digestive system adapts

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