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Obesity affects 42% of adults in the United States and is strongly associated with major cardiovascular disease risk factors, including high blood pressure, abnormal cholesterol levels, and insulin resistance, making effective obesity treatment a critical public health priority.

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Among patients with obesity, semaglutide 7.2 mg reduced body weight by more than 18% for those without diabetes and by more than 13% for those with diabetes, according to the results of the STEP UP and STEP UP T2D trials

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“Treatment guidelines recommend weight reduction and physical activity as first-line management for obesity-related knee osteoarthritis,&rdquo

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