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Subcutaneous injection of drugs: literature review of factors influencing pain sensation at the injection site

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Our retrospective cohort study showed results consistent with Uedas work, indicating that GLP-1RAs were not associated with a significant risk of intestinal obstruction compared to SGLT2 inhibitors

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Inflammation, metaflammation and immunometabolic disorders

However, despite affinity, albeit lower, of tirzepatide for the GLP-1 receptor, tirzepatide had no effect on body weight, food intake, fasting insulin, endogenous glucose production and insulin-stimulated glucose uptake in skeletal muscle and subcutaneous white adipose tissue of GLP-1 receptor knockout mice [89]