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faecalis supernatants were capable of disrupting the colonic epithelial monolayer and cleaving GLP-1 in a gelE-dependent manner (Levalley et al., 2020)

Rapid weight reduction induced by GLP-1based therapies has been associated with proportional losses in fat-free mass in adult populations, raising concerns regarding potential impacts on skeletal muscle accrual during adolescencea developmental period characterized by dynamic changes in body composition and linear growth

Fras J.P., Davies M.J., Rosenstock J., Prez Mangui F.C., Fernndez L., Bergman B., et al

Adipose lipid turnover and long-term changes in body weight

You may benefit from a longer initial treatment course, a more gradual taper, or a commitment to maintenance dosing rather than complete discontinuation