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[DOI] [PMC free article] [PubMed] [Google Scholar] 224.Maclean P.S., Bergouignan A., Cornier M.A., Jackman M.R

Unlike medications that require precise timing around meals or sleep, retatrutide operates on a pharmacokinetic profile designed for once-weekly administration

Injection sites should be rotated

Severe vomiting, dehydration, abdominal pain, or allergic symptoms need prompt care

Next, we estimated the per-protocol effect by accounting for treatment changes and discontinuation, reflecting real-world drug exposure

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