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Dehydration can cause headaches, fatigue, and constipation, all of which mimic or worsen GLP-1 side effects

"Reductions in Insulin Resistance Are Mediated Primarily via Weight Loss in Subjects with Type 2 Diabetes on Semaglutide." The Journal of Clinical Endocrinology & Metabolism , vol

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There is early evidence that these benefits go beyond what might be expected due to the drugs metabolic effects

95% CI 1.6, 0.39), phentermine/topiramate (WMD: 0.7

However, the FDA has been looking into investigating if semaglutide and tirzepatide would be an exception to that, due to their complexity