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Description
The first STEP trial (a series of large clinical trials that investigated who semaglutide helps and in what context) reported a 14.9% reduction in body weight over 72 weeks for participants taking 2.4 mg weekly

The nutrition guidance is fairly straightforward
P = 0.001)

Sitagliptin inhibited plasma DPP-4 activity, improved lipid tolerance, and increased plasma active GLP-1 in Dpp4 EC+/+ (BMT) mice (Figure 3, E and F)

Not losing weight despite dose increases
0, no obvious effect