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The aforementioned observation was also accompanied by decreased mean glutamate-induced current densities.Reference Adams, Pei and Sandoval 27 Similarly, GLP-1 RA administration inhibited A142-induced increases in intracellular calcium concentrations in hippocampal slices of Sprague Dawley rats.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Administration of AP-5 and nifedipine, N-Methyl-D-Aspartate (NMDA) receptor antagonists, also inhibited Abeta142-mediated increases in intracellular calcium concentrations

Does Tirzepatide Actually Burn Fat or Just Reduce Appetite

The supply issue doesnt seem to involve the drug itself, but the delivery system

DiMeglio LA et al
Most doctors prescribe 500mg of Metformin (Glucophage) before eating.

Since GLP-1 drugs also have an effect on inflammation and the immune system, theoretically combining them with biologics could create a heightened risk of infection or immune-related issues
