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These impurities are then: Separated using high-resolution HPLC or UPLC Identified by accurate mass measurement via HRMS Structurally confirmed through amino acid sequencing by HRMS, NMR, or complementary techniques This process ensures that degradation products observed during long-term stability are already understood, characterized, and controlled

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Nevertheless, the integration of two-year outcomes, rigorous propensity matching, millions of clinical notes analyzed through validated AI models, and one of the largest GLP-1RA-treated cohorts studied to date provides a robust characterization of real-world treatment heterogeneity

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Psychiatry 11 , 169177 (2003)