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[46] through a combination of coimmunoprecipitation, RNAi knockdown, immunoblotting, cAMP assays, and pharmacological assays demonstrated that -Arrestin-1 knockdown broadly attenuated GLP-1 signaling, causing decreased ERK and CREB activation and IRS-2 expression as well as reduced cAMP levels and impaired insulin secretion
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The SURMOUNT-1 trial demonstrated up to 20.9% mean body weight reduction at the 15 mg dose over 72 weeks
