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In rats, therefore, the appetite suppressing effects of these drugs do not show a sex bias

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Ambery P, Parker VE, Sumvoll M et al (2018) MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomized, controlled, double-blind, ascending dose and phase 2A study

In these trails, GLP-1RAs exerted renoprotection, irrespective of the baseline HbA1c (Kristensen et al., 2019)

The plateau itself lasted through week 48 with an average regain of only 0.8 kilograms, demonstrating ongoing maintenance effects

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