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This is anecdotal and not clinically proven, but some users report it

The SURMOUNT2 and 3 trials were not included in the present analyses due to aspects of the study design that were expected to affect the time to weight plateau (type 2 diabetes population in SURMOUNT2 and a 12week leadin on an intensive lifestyle modification programme in SURMOUNT3)

E., Shu, I., Rometo, D., Arnold, J., Korytkowski, M., & Luo, J
While mild gastrointestinal symptoms are common with tirzepatide and often resolve with continued therapy, certain presentations warrant prompt medical evaluation

The clinical trial data proves this conclusively
