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In August 2025, a review found that flavonoids, which contribute to bitter flavors in, say, citrus or hops, can stimulate GLP-1 release, too

The GLP-1R is expressed in the heart and vasculature, suggesting that GLP-1R agonism may have direct actions on the cardiovascular system

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Skovbjerg G, Roostalu U, Salinas CG, Skytte JL, Perens J, Clemmensen C, et al

Rapid weight loss from appetite suppressants can increase concern about muscle loss and protein inadequacy, particularly when total caloric intake falls substantially

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