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95% CI, 0.69-1.57), and 2.9 years with 2-year gap and tail periods (HR, 0.99
Thus, pharmacological treatment can have an important impact on gut microbiota, and in turn, gut microbiota can induce pharmacodynamical alterations by transforming drugs or by modifying host metabolism and immune system [244, 245]
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Orlistat (Xenical, Alli): A lipase inhibitor that blocks the absorption of fat in the gut
n = 4,668) or placebo ( n = 4,672), with both groups also receiving standard care (treatment period: 3.55 years)
