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These substances cant be targeted to a specific area and may instead activate pathways in tissues and systems that are actually detrimental to health, says Taylor

To view digital features for this article go to Introduction Obesity (defined as a body mass index [BMI] 30 kg/m 2 in adults [1]) is a major health concern in the USA [2] and is associated with multiple complications, including cardiovascular disease, type 2 diabetes, and osteoarthritis [3,4,5,6,7,8]

Miranda S, Choudhari J, Chauhan N, Parmar MS

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Saxena, MD, on semaglutide and how it works to help drop the weight for good