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But beyond managing type 2 diabetes and obesity, researchers are uncovering a surprising new benefit: a connection between GLP-1s and skin health

Results Glutamine was a more potent GLP-1 secretagogue than glucose or other amino acids, increasing GLP-1 release 7.10.7-fold ( n =19) at 10 mmol/l, with an estimated median effective concentration of between 0.1 and 1 mmol/l

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Similarly, serotonin levels did not change after insulin injection in mice (2 U/kg, i.p.) (Supplemental Figure 16, D and E) as compared with equal-volume saline at either 15 minutes (insulin: 430 166 ng/mL

Recently, first clinical observations have emerged suggesting that GLP-1RAs may improve inflammatory skin diseases, including psoriasis [18], hidradenitis suppurativa [19], and atopic dermatitis [20], but the pathophysiologic pathways behind these observations remain speculative