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GLP-1 receptors in the mesolimbic dopamine system particularly the ventral tegmental area and nucleus accumbens modulate the dopamine release that reinforces addictive behavior

These findings are consistent with previous trials with liraglutide at doses up to 2.0 mg in T2DM, 13, 28, 29 and in a phase 2 dose-finding trial in obese individuals without T2DM, 9 about 30% of whom had prediabetes at baseline

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