how were glp 1 agonists discovered History of glucagon-like peptide-1 receptor PDB-101: Molecule of the Month:

Early on Tschp noticed that obese mice lost weight when infused with one of DiMarchi's new glucagon peptides

However, discontinuation often leads to weight regain and loss of cardiometabolic benefits, 42 , 87 suggesting that, as with traditional antihypertensive drugs, sustained BP control may require ongoing use

They work by lowering arterial blood pressure, which, in turn, reduces the risk of MACE [7,11]

Relationship between GLP-1 and obesity Genetics, the environment, and other variables all have a role in the development of obesity, a complicated condition defined by the abnormal buildup of excess fat

Just know this has not yet been evaluated in clinical trials

Intern Med