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Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal mra compared with conventional care in patients with type 2 diabetes and albuminuria

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doi: 10.1016/S0140-6736(10)60307-8 25

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Collectively the ex vivo experiments support a direct effect of GLP-1 on the hearts sinus node, which is mediated through the GLP-1 receptor
