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Table 2 gives an overview on the cardiovascular safety data of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, and sitagliptin

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Therefore, if the duration of diabetes and the follow-up observation period of the included study subjects are insufficient, it may be difficult to determine whether the absence of DR during the observation period is due to the protective effect of the drug or individual factors, potentially leading to false-positive or false-negative results

The primary endpoints were the change in body weight and the proportions of patients losing at least 5% and 10% of their initial body weight

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