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When two agonists bind the same receptor, the second one isn't adding a new signal it is competing for finite binding sites on a pathway that is already being stimulated

For instance, in May 2025, according to the WHO, 1 in 8 people globally were living with obesity, with 2.5 billion adults overweight, including 890 million with obesity

Survodutide targets GLP-1 and glucagon receptors

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When there were more than four levels in any factor (e.g., 12 time bins), a Greenhouse-Geisser correction was used to determine statistical significance