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Off-patent semaglutide expansion across major global markets is also expected to increase competition and broaden overall patient access

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The umbrella review included thirty-one RCTs involving 165,858 participants with either T2DM, prediabetes, or at high risk of diabetes (Zhu et al., 2020)

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The most common side effects are gastrointestinal, with nausea occurring in 15-44% of patients, followed by vomiting, diarrhea, constipation, and abdominal discomfort

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Who Is Most at Risk for GLP-1-Related Joint Discomfort Individuals with a family history of arthritis, prior joint injuries, or inflammatory conditions may be more vulnerable to joint pain during GLP-1 therapy

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The suppression of food intake and resulting weight loss provides essential advantages for patients who struggle with obesity or complications from excessive weight [6]

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It is commonly associated with supporting processes related to weight management, appetite regulation, and overall metabolic function

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