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This article summarizes the milestones in the development of insulin icodec leading to this first approval for diabetes mellitus.

Both tirzepatide (since 2022) and semaglutide (since 2024) were placed on the shortage list, prompting a surge in sales of compounded alternatives
Researchers implanted electrodes in the human nucleus accumbens to track brain activity during severe food preoccupation in an individual taking tirzepatide

The prevalence of prediabetes has more than doubled over the past two decades
