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This bridging approach can help maintain appetite control while the tirzepatide dose decreases

Retatrutide is a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide1 (GLP1) receptor agonist

Although direct monitoring of fetal blood glucose concentrations immediately post-Sem injection was not performed, the absence of a reduction in the body weights of fetuses from glucose-supplemented dams discounts the notion that the decrease in fetal glucose levels is responsible for the fetal growth restriction induced by maternal GLP-1R activation

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It achieved a reduction in HbA1c of up to 2.3% and body weight losses exceeding 22% over 72 weeks

however, population-based studies have yielded more mixed results and no causal link has yet been established [23,24]