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For many people, this can be lower than the maximum dose, as long as it continues to support appetite control without ongoing side effects

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disordered taste, such as a reduced ability to taste or having a bad, metallic taste at all times)

Accepting this reality and planning for it produces better outcomes than hoping for exceptional results

Bernink FJ, Timmers L, Diamant M, Scholte M, Beek AM, Kamp O, Marques KM, Denham RN, Chen WJ, Doevendans PA, et al: Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction: the EXAMI study

Factors influencing this decision include: GI sensitivity Blood sugar control needs Medication half-life I personally have seen patients switch without the need for a washout period except for on rare occasions when they experience severe side effects from semaglutide Potential Benefits of Switching to Tirzepatide Potential Benefits of Switching to Tirzepatide Switching from semaglutide to tirzepatide may offer several potential benefits, especially for individuals who havent achieved their target weight or glycemic control