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Description
One important debate concerns the mechanisms underlying GLP-1RA benefits in non-metabolic diseases
Consequently, activation of these receptors produces a small but consistent chronotropic effect
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In particular, glucagon has firmly been demonstrated to enhance hepatic lipid metabolism, Hepatic GCGR agonism leads to upregulation of lipid catabolism pathways in the hepatocyte where a number of key regulatory transporters and enzymes facilitate beta oxidation of fatty acids (61)
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