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Thyroid Function Monitoring For patients established on levothyroxine, thyroid function tests (TSH and free T4) should be monitored according to standard protocols: Every 612 months once stable on an established dose 68 weeks after any dose adjustment 68 weeks after starting or changing the dose of Saxenda After significant weight loss or gain More frequently if symptoms of hypo- or hyperthyroidism develop Patients should report symptoms suggesting inadequate thyroid replacement (fatigue, cold intolerance, weight gain, constipation) or excessive replacement (palpitations, tremor, anxiety, heat intolerance, unintentional weight loss)

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It is reasonable to expect that, if retatrutide receives approval, comparable principles will apply