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GLP-1 also affects food intake, body weight, and has direct effects on the heart (52, 103)

Jhala et al., 2003)

While rare, GLP-1 receptor agonists can have serious side effects, including gastrointestinal issues, thyroid cancer, pancreatitis, liver injury and kidney problems

GLP-1 receptor agonists are incretin-based therapies that: Enhance glucose-dependent insulin secretion Suppress glucagon release Slow gastric emptying Promote satiety and weight loss Common medications include: Semaglutide Tirzepatide Dulaglutide Liraglutide Their ability to delay gastric emptying is central to both their therapeutic benefits and perioperative risks

(1) By binding to GLP-1 receptors, Semaglutide: Enhances insulin secretion Suppresses glucagon release (which reduces blood sugar levels) Delays gastric emptying Promotes satiety These combined actions have been shown to help regulate blood sugar levels and reduce appetite

Semaglutide injectable or pills used in the treatment of type 2 diabetes and obesity in Singapore.