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Data from the STEP [52] and SUSTAIN [53, 54] trials consistently demonstrate that the substantial weight loss achieved with semaglutide at doses of 0.5 mg, 1.0 mg, and 2.4 mg is largely independent of these symptoms, with less than 1% of the total weight loss benefit attributable to GI AEs

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The percentage of patients receiving GLP-1 medications both before and after bariatric surgery also showed steady growth, rising from 0.5% in 2018 to 3.3% in 2023, calling into question the extent to which GLP-1s are a replacement versus a supplemental therapy

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I keep an eye on this space because, despite considerable issues with nausea, vomiting, muscle loss, and even rare cases of sudden blindness, the GLP-1 RA drugs may offer the first real hope for patients with metabolic syndrome associated with chronic ulcers