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Neuron (2017) 96(4):897909

Nannipieri M, et al

While clinical trials and real-world data have proven them to be highly effective for blood sugar control in people with type 2 diabetes, they may also have other health benefits, including significant weight loss for people with obesity and overweight

Sequential use is preferred: try Orlistat first, then transition to Wegovy if needed for more significant weight loss

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-

If you are curious about it anyway, raise it with your prescriber rather than layering it in on your own