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The complex interaction of factors such as insulin resistance, glucotoxicity and lipotoxicity contribute to the pathogenesis and coexistence of diabetes and metabolic-dysfunction associated steatotic liver disease (MASLD) in a reciprocal process of exacerbating the underlying conditions [9]

By simultaneously targeting all three receptors, retatrutide is hypothesised to deliver additive effects on appetite suppression, insulin secretion, and energy expenditure

There are now, having said that, there's a way to marry the two and kind of amplify the two