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The side effects observed were [31]: Nausea (24% of participants) Diarrhea (21%) Vomiting (14%) Constipation (8%) Dyspepsia (7%) Injection site reactions (3%) Cholelithiasis (less than 1%) Pancreatitis (less than 1%) Gastrointestinal side effects were the most common reason for discontinuation and their severity varied from mild to moderate

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Researchers should factor this into the study design

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Common justifications include a non-standard dose, addition of B12 or other ingredients, or an alternative delivery route