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GLP-1 receptor agonists and dual GLP-1/GIP co-agonists can produce substantial weight loss, but caloric restriction and weight loss trigger adaptive thermogenesis and neuroendocrine changes (reduced energy expenditure and increased appetite) that facilitate weight regain once therapy is discontinued

Meta-analyses have confirmed the benefit of GLP-1 RAs as a class in both secondary and primary prevention of cardiovascular disease, and in reduction of adverse kidney outcomes in people with T2D (Kristiensen et al, 2019

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[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Mohanannair Geethadevi G, Quinn TJ, George J, et al

Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as particularly promising pharmacologic agents for managing weight regain after bariatric surgery, leveraging mechanisms that complement the physiological effects of surgical intervention
