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Rev Gastroenterol Mex

Memantine, a noncompetitive NMDA receptor antagonist, attenuates glutamate-induced excitotoxicity by non-competitively blocking overactivated receptors, thereby protecting neurons from calcium overload and providing modest preservation of daily functioning in moderate-to-severe AD, but similarly fails to modulate tau pathology or proteostatic mechanisms [80]

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Using formic acid (FA) instead of trifluoroacetic acid (TFA) as the ion-pairing reagent required gradient adjustment due to FAs weaker acidity and lower hydrophobicity

To find the patients who may have been prescribed the drugs, researchers focused on people who were diagnosed with obesity at least 90 days before starting the prescription drugs