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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]

Ongoing clinical trials are planned, including evaluating tirzepatide as adjunctive therapy in individuals with a BMI over 27 who are already receiving infliximab or adalimumab treatment (NCT06774079)

Clinical Evidence on Weight Loss Maintenance with Continued Treatment Long-term semaglutide therapy demonstrates sustained weight loss when treatment continues without interruption

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During a peptide consultation, Dr

Future work is needed to determine whether GLP-1 exposure directly contributes to ischemic optic neuropathy or whether unmeasured factors are driving the observed association