astria therapeutics glp-1 receptor agonist weight management diabetes treatments Evolution of GLP‐1 Agonists for Treatment Randomised trial comparing weight loss
Description
Current evidence suggests GLP-1 receptor agonists have a neutral effect on fracture risk, though bone mineral density changes may occur indirectly through substantial weight loss
doi:10.1016/j.cgh.2023.08.034 70
doi: 10.1016/j.ejphar.2012.12.012 143 McCleanPLJalewaJHolscherC
With regard to adverse effects, gastrointestinal intoleranceespecially nausea and vomitingrepresents the class-defining limitation
Clinical outcomes of tirzepatide or GLP1 receptor agonists in individuals with type 2 diabetes
Likely, multiple mechanisms contribute
