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But tirzepatide still activates GLP-1 receptors (albeit with different potency), so the "rest" for GLP-1 receptors during tirzepatide use is not complete

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Madeira et al., 2024)

[DOI] [PubMed] [Google Scholar] 73.Sattar N, Lee MM, Kristensen SL, Branch KR, Del Prato S, Khurmi NS, et al

[DOI] [PubMed] [Google Scholar] 63.Sedeo-Diaz J., Ruiz-Serrato A., Vallejo-Herrera M.J., Villar-Jimenez J., Gomez-Lora D., Garcia-Ordoez M.A

Thus, a depletion of Ca 2+ stores did not explain why JWU-A021 failed to raise the [Ca 2+ ] i when the SES contained 100 nM Ca 2+