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Soft tissue and altered biomechanics in patients with a high BMI can make surgical exposure and component placement more challenging, leading to prolonged operative times

N Engl J Med 373:21172128 Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR (2017) Canagliflozin and cardiovascular and renal events in type 2 diabetes

Among these, uncontrolled diabetes can progress to ketoacidosis, a potentially life-threatening condition

Table 1 summarizes the key findings from these ten studies

When it comes to meaningful, sustained weight loss, this rarely leads to proven results
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