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Realistic Expectations: What Clinical Research Shows Clinical Research Context: Studies evaluating FDA-approved semaglutide and tirzepatide have shown that participants combining these medications with diet and exercise can achieve meaningful weight loss-typically 15-20% or more of body weight over 12-18 months

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Helpful markers may include: Evaluating hormone and thyroid function may be especially helpful for people with stubborn abdominal weight gain, fatigue, or symptoms suggesting metabolic slowdown

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The morning after, prioritize electrolyte-rich fluids before coffee or food

They came to this conclusion by reviewing cases of suicidal thoughts or actions reported to the FDA Adverse Event Reporting System