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Discussion In this study, we have identified how single amino acid substitutions to exendin-4 can dramatically enhance insulin secretion via modulation of GLP-1R binding kinetics, biased signaling, and trafficking

Because of this, it was especially important to know if drugs commonly used to treat type 2 diabetes like those in the GLP-1RA class might help explain the association

[DOI] [PubMed] [Google Scholar] 69.Peng Z.Y., Yang C.T., Lin W.H., Yao W.Y., Ou H.T., Kuo S

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Insulin, sulfonylureas, narrow-therapeutic-window medications, and any drug where absorption timing matters are all worth flagging

Inflammation 44 , 10491059 (2021)