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Description
The 20.9% incidence of dysesthesia (abnormal sensations) raises questions

If youre starting tirzepatide, one of the first questions youre likely asking is how quickly it will actually curb your appetite
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Concomitant administration of topiramate with alcohol can result in significant CNS depression
"Thats why these taste shifts are often more pronounced early on, and tend to settle once the patients weight stabilises." Other theories include the presence of GLP-1 receptors in taste buds themselves, which may alter how we process flavour, and the slowing of digestion, which can make foods feel heavier and affect how theyre perceived in the mouth

Room temperature or slightly warm water is less likely to trigger reflux than ice-cold water, which can cause stomach contractions

If the drug is taken once a week, the dose should be postponed until after surgery
