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& Hooper, N

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In terms of insulin secretion, it should be noted that while sitagliptin is not considered an insulin sensitizer, it has been observed to decrease plasma insulin concentrations, perhaps by influencing better pancreatic beta cell function in our studies showed a significant decrease in insulin secretion, even with greater change delta than in the metformin group, however it must be considered that both the metformin group and the COMBO group started with increased insulin resistance and concentrations of insulin were not as low as those observed in the metformin group

Borup C, Vinter-Jensen L, Jrgensen SPG, et al
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