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In support of this hypothesis, hormone replacement therapies (HRT) that include estradiol have been shown to improve insulin sensitivity and lower blood glucose levels (164166)

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The SURMOUNT-1 trial validated this approach with 20.9% body weight reduction

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population

PeerJ 7:e7359 Parks DH, Imelfort M, Skennerton CT, Hugenholtz P, Tyson GW (2015) Checkm: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes

Some states have expanded coverage to include weight management indications, while others restrict coverage to diabetes treatment only or require prior authorization