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The standard tirzepatide dosing schedule starts at 2.5 mg for four weeks, then increases in increments every four weeks to the target maintenance dose

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In PIONEER 8, compared with patients receiving basal or premixed insulin, patients receiving basal-bolus insulin appeared to have a greater duration of diabetes (13 and 14 years vs 16 years, respectively), greater body weight (85 and 78 kg vs 89 kg) and a higher total daily insulin dose (35 and 48 U vs 79 U) (Table 2(ii))

Semaglutide maintains therapeutic levels for seven days, so minor timing shifts (hours) don't significantly impact effectiveness

However, drug prices fluctuate and vary by pharmacy, and the actual out-of-pocket cost varies by pharmacy, location, and insurance coverage

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