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At the genus level, the semaglutide or calorie restriction group shows a higher relative abundance of Allobaculum compared with the HFD group

Low GLP-1 and GIP levels shaped treatment outcomes The analysis of pharmacological response indicated that participants in the three profiles characterized by the low GIP tertile achieved optimal response to tirzepatide, irrespective of GLP-1 levels

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Moreover, it has been shown to reduce blood pressure, along with levels of total and low-density lipoprotein cholesterol, fasting glucose, insulin, and inflammatory markers [41,42]
