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Diabet Med 32(6):725737 Khunti K, Seidu S, Kunutsor S, Davies M (2017) Association between adherence to pharmacotherapy and outcomes in type 2 diabetes: a meta-analysis

Tracy Norfleet, MD, FACP, notes: "Injection site reactions may get worse over the first 24 hours, and should improve thereafter
This means theres less oversight of how effective they are, and product quality can vary between brands

Frequent vomiting or acid reflux that isn't improving

While semaglutide may not be as powerful as its successors, it remains a valuable and effective option for many patients

Fat storage changes