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Month 13 What to expect: Weight loss becomes more noticeable Average loss: 48 lbs per month Appetite control improves Dose titration increase effectiveness Energy and digestion start to feel more balanced By now, clients usually feel the difference, not just on the scale, but in their daily routine

For these medications to be most effective, they need to be paired with a healthy diet

Microvascular dysfunction as a systemic disease: A review of the evidence

A large number of bioactive molecules can be cleaved by DPP-4 in vitro , but only a few of these have been demonstrated to be physiological substrates

doi: 10.1038/ijo.2016.154 89 LiuYLiuHLiZFanHYanXLiuXet al

Build a de-escalation pathway from day one