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Across the subgroups of patients with different baseline cardiovascular conditions, mean age ranged from approximately 59 to 67 years, baseline BMI from 33.8 to 36.3 kg/m 2 , and baseline type 2 diabetes prevalence from 25.4% in aortic disease to 50.8% in heart failure, with broadly balanced matching across the individual subgroups (Table 2)

doi: 10.1111/dom.13613 123 NauckMAMllerTD

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The main difference is that mazdutide targets both GLP-1 and GCG receptors, while semaglutide mainly targets GLP-1 receptors