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The least-squares mean percentage weight reduction was 8.7% in the 1-mg group, 16.3% in the 4-mg group with an initial dose of 2 mg, and 17.8% in the 4-mg group with an initial dose of 4 mg

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Until these trials are complete and regulatory submissions are made, the full picture of retatrutide's side effect profile including the true burden of nausea in real-world use remains to be established