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Action of GLP-1 on the pancreas Physiology of GLP-1 as an incretin The primary action of GLP-1 for lowering blood glucose is the stimulation of insulin secretion by potentiating the action of glucose (20, 74, 80, 125)

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Anyone with a BMI of 30 or above, or 27 with at least one weight-related comorbidity, meets the standard prescribing criteria for GLP-1 therapy

Recent systematic evaluations found no higher rate of UTIs with GLP 1 therapy compared with other diabetes medications

Specifically, they proposed an approach in which GLP-1RAs could be prescribed for an initial period of weight loss before patients transitioned to cheaper alternative interventions for weight maintenance such as lower-cost medications, behavioral health programs and support from nutritionists

The use and popularity of incretin mimetics have recently accelerated due to compelling data demonstrating an improvement in major clinical endpoints for patients with T2D and a reduction in cardiovascular events